Qaidam Basin is one of coexistence basins of multiple energy minerals including oil, natural gas, coal and uranium in China. According to the plane distribution, petroleum reservoirs developed distribute in the west, north margin and east of Qaidam Basin, coal and sandstone type of uranium deposit distribute in north margin; according to the occurrence layer, the hydrocarbon source rocks of oils and part gases including oil-type gas and coal-bed gas are from Jurassic coal strata, and the reservoirs are mainly Jurassic and Paleogene-Neogene, and coal is hosted in Jurassic Dameigou Formation and Xiaomeigou Formation, and uranium mineralization develops in Jurassic and Paleogene-Neogene. Combined with the temporal-spatial distribution of single energy mineral and the composition form between them, multiple energy minerals including oil, natural gas, coal and sandstone type of uranium deposit have significant coexistence in Qaidam Basin and have interaction between them. There are coexistence between oil and gas in the northwest of Qaidam Basin and between coal and coal-bed gas in the north margin; uranium mineralization develops above coal-bearing strata in the north margin of Qaidam Basin, and there are several uranium mineralized points in the edge directed by petroleum migration, and petroleum and coal strata provide reductant for uranium metallogeny. Rased on the hydrocarbon-generating simulated experiment of hydrocarbon source rocks in north margin of Qaidam Basin, the accumulation of U and the associated elements (Mn, Mo, V and Cs) has significant catalytic action on hydrocarbon-generating, indicating that the quantity of hydrocarbon-generating increases drastically, and the peak of hydrocarbon-generating is moved forward. In general-organic, minerals have important reducing action on the formation of inorganic uranium deposit, and the inorganic uranium deposit and the associated elements have significant catalytic action on the formation of organic petroleum.