The extraction of manganese from low-grade manganese oxide ores using CaS derived from CaSO₄as reductant was investigated. The effects of mass ratio of CaS to ore, reduction temperature, reduction time, liquid to solid ratio (L/S ratio), stirring speed, leaching temperature, leaching time and H₂SO₄concentration on the leaching rates of Mn and Fe during the reduction–acid leaching process were discussed. The leaching rates of 96.47% for Mn and 19.24% for Fe were obtained under the optimized conditions of mass ratio of CaS to manganese oxide ore 1:6.7, L/S ratio 5:1, stirring speed 300 r/min, reduction temperature of 95 °C for 2.0 h in the reduction process and leaching stirring speed of 200 r/min, H₂SO₄concentration of 1.5 mol/L, leaching temperature of 80 °C for 5 min in the leaching process. In addition, this process can be employed in the recovery of manganese from various manganese oxide ores, and Mn leaching rate above 95% is obtained.