The Ethiopia Rift System (ERS) is a section of the East African Rift System within Ethiopia extending from the Afar in the northeast to the Kenya border in the southwest. It is apparent that magmatism and magmatic intrusions influence the crustal shape in the ERS resulting in its thinning and the shallowing of magmatic sources at various locations within it. As a consequence, more than 31 volcanoes hosting hydrothermal structures with a conceivable potential to generate massive quantities of geothermal energy have been identified along the ERS. In this study, we map the Curie Point Depth (CDP) over the ERS based on the analysis of aeromagnetic data extracted from the World Digital Magnetic Anomaly Map. Spectral evaluation method was used to estimate the boundaries (top and bottom) of the magnetized crust. Reduced-to-pole (RTP) aeromagnetic records have been divided into 105 (50% overlap) square blocks of 200 × 200 km size. The Curie temperature (580 °C) of magnetite was used to determine the thermal gradient and the heat drift in the area. The depths obtained for the bottom of the magnetized crust are assumed to correspond to the Curie Depths, where the magnetic layer loses all its magnetization. The determined values of Curie Point Depth, geothermal gradient and heat flow for the 50% overlapped 105 blocks, respectively, range from 8.85 to 55.85 km, 10.38 to 65.54 °C/km and 25.96 to 163.84 mW/m2. Lower CPD (< 20 km) in the ERS was obtained between Mille and Gewane (southwest Afar), between Adama (Nazret) and Yerer (NMER) and between Wendo Genet and Koti (SMER) localities. These areas, showing low CPD, exhibit excessive geothermal gradient and high heat flow all of which indicate the presence of significant geothermal potential.