In northern Chile, economic activities related to mining and thermoelectric energy have existed in the city of Tocopilla since the early 1900s and metal concentrations in soils have likely been altered by historic anthropogenic activities. To assess the concentrations of Cu, Zn, Pb, Ni, Co, and Cr in urban soils of Tocopilla, a total of 70 superficial (2 cm) and 70 deep (20 cm) soil samples were collected in 2014. Furthermore, to analyze concentration changes in soils over time, 18 superficial (5 cm) samples were collected in 2020–2021. A numerical evaluation (geoaccumulation index, and enrichment factor), principal component analysis, and spatial distribution approach were applied to infer geogenic and anthropogenic influence on the concentrations of these elements. The main conclusions of this research indicate that urban soils of Tocopilla contain geogenic Cu, Zn, Pb, Ni, Co and Cr. However, elevated concentrations of Cu, Zn, and Pb cannot be attributed to a geogenic origin alone, as a proportion of their enrichment is considered to be anthropogenically sourced. The contamination of anthropogenic elements has been found to be related to historic copper mining and thermoelectric energy production. Furthermore, when compared to other sites globally, median concentrations of Cu (945 mg/kg in 2014 and 823 mg/kg in 2020) and Zn (305 mg/kg in 2014 and 196 mg/kg in 2020) in superficial urban soils are among the highest worldwide. Regarding 2020–2021 sampling, Zn and Pb concentrations have increased, while Cu, Cr, Co, and Ni have remained similar to the 2014 samples.