A good understanding of aquifer hydraulic properties is vital in the management of groundwater resources and in the determination of aquifer potentiality and its vulnerability to surface environment contamination. Results obtained from the integration of well bore-constrained geo-electric sounding data from Udi and Ezeagu areas, southeastern Nigeria, were utilized in the estimation of vital aquifer hydraulic characteristics such as transverse resistance, longitudinal conductance, hydraulic conductivity, and transmissivity. The correlation of these data sets constrained the sub-surface geology of the study area into five distinct stratigraphic units, namely, from top to bottom: lateritic soil, clayey/shaly sand, fine grained sand, medium grained sand, and clayey sand. Consequently, the resistivities and thicknesses, respectively, of the sub-surface layers range from 524 to 1003 Ωm and 5.10 to 25.50 m; 283 to 524 Ωm and 15.3 to 29.53 m; 765 Ωm to 1523 Ωm and 80.65 to 96.93 m; 180 to 327 Ωm and 80 to 120.50 m; 424 to 718 Ωm. The medium-grained sandstone unit with the least resistivity value is the designated economic aquifer. From the results, the estimated range of distribution of pumped aquifer hydraulic conductivity varied between 50 and 850 m s−1 across the entire study area while pumped transmissivity values ranged from < 5000 to 100,000 m2 s−1. The distribution of the hydraulic conductivities and transmissivities determined from the boreholes and sounding data is similar in pattern throughout the entire study area. Based on these parameters and the local hydrogeology, the investigated area was sub-divided into three aquifer potential zones (low, moderate, and high). High to moderate potential aquifer systems were traced to the northeastern, southwestern, northwestern, and central parts of the investigated area. The average values of other Dar-Zarrouk parameters are 0.3793 mhos for longitudinal conductance and 361,061.47 Ωm2 for transverse resistance. In addition to the north-central axis, the lowest values (< 0.05 mhos) of longitudinal conductance (LC) are observed within a small elliptical region located at the eastern axis of the area. These areas are characterized by poor aquifer protective capacity, which renders the aquifer systems here vulnerable to contamination from industrial effluents and domestic wastes. This is exacerbated by the presence of shallow and relatively shallow aquifers in these areas. In areas of similar geologic framework, this technique can be used to determine the potential of homogeneous aquifer systems as well as their vulnerability to surface environment contamination.