Celestine and barite mineralizations occur in the Upper-Paleocene unit of marly-clay within curdled limestone of the Siouf-Cherahil area, North-South axis, Central Tunisia. The particularity of celestine is the high contents of U and it has never been studied as same as the Ba-rich deposit of Cherahil zone. This work was undertaken to narrow this gap. For this, mineralogical and geochemical characteristics of celestine and barite nodules were investigated using X-ray fluorescence, X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. At the Siouf zone, the mineralogical and geochemical data indicate that celestine contains more than 45% of Sr and U rate has a wide distribution and can reach 0.64%. Similarly, the values of P2O5 are around 3.50%. Statistical analysis showed a high positive correlation between U and P, indicating that U had a strong affinity with P. In Cherahil zone, barite record considerably high barium values. The Siouf-Cherahil deposit reports huge proportions of sulfate minerals along the solid solution (Ba, SrSO4). These deposits display high contents of BaO, SrO, and SO4 and significant amounts of U and P with trace amounts of Y, Ni, Zn, Zr, Cr. The main process responsible for celestine and barite crystallization is the early diagenesis from interstitial fluids. The mineralization is located in trap structures and privileged zones created by synsedimentary tectonic events. In such available spaces, celestine concretions could be developed under several textural types: fibrous, granular, saccharoid, and hyaline automorph.