Although intersection zones of two or more fault arrays have been identified as favorable loci of unconformity-related basin-basement mineral deposits in previous studies, their roles in controlling fluid flow patterns related to formation of oriented-, and structurally-controlled mineral deposits remain unclear. In this study, 3-D hy-dromechanical models were conducted to better understand the response of a natural fault intersected by a hydraulic fault under different stress regimes. A comprehensive parametric study was carried out to assess the roles of fluid pressure, burial depth, basin permeability, intersection angle, and horizontal differential stress on the hydromechanical response of a system containing two intersecting faults. Depending on basin sediment permeability, fault intersection angle, and horizontal differential stress, the fluid flow either stops, crosses, or diverts toward natural fault. Among the tested parameters, the intersection angle, and horizontal differential stress have the most noticeable effect on the fluid flow in the system. The critical intersection angle at which the fluid flow diverts toward the natural fault varies between approximate to 27 degrees in normal faulting regimes, to approximate to 55 degrees, in both strike-slip and reverse faulting regimes. Conversely, burial depth and fluid pressure have no significant effect on fluid flow diversion in the intersection zone. The results are in agreement with field observations related to the unconformity-related uranium deposits found in northern Canada.