Taking the Baiyanghe uranium deposit in Xinjiang as an example, the authors used the 3D geologic modeling and analysis software SKUA-GOCAD to establish a 3D geologic model of its topography, structure, stratum, granite, and ore body based on the study and knowledge of the geologic background, characteristics, and metallogenic rules of the deposit. Meanwhile, the authors summarized the 3D prediction model, conducted a quantitative extraction and analysis of favorable metallogenic information, and carried out the 3D prediction and study on the Baiyanghe uranium deposit by combining the 3D weights of the evidence method and the 3D informational method. Based on the analysis and prediction results, the deep prospecting target area was delineated. The 3D metallogenic prediction of the uranium deposit was achieved, which has provided technical support for the exploration of the Baiyanghe uranium deposit and a beneficial reference for the 3D metallogenic prediction of other minerals. Such a practice can provide a certain practical application value and a reference value for the research in this field.