In-situ leaching is the main way to realize fluidization mining of deep uranium ore, which has the characteristics of safety, low pollution and low cost. However, deep uranium mining is under high temperature and high pressure, which greatly affect the permeability of uranium deposit. The sandstone-type uranium deposits were taken as the research object in this paper, and a multiphase and medium flow experimental simulation system were used for solution seepage experiment under the action of temperature and confining pressure. Based on the permeability data obtained during the experiment, Origin software was used to process the experimental data. The results indicated that the permeability of sandstone-type uranium ore increased with temperature increased and decreased with confining pressure increased. The influence of temperature on permeability was higher than that of confining pressure. According to the trend of permeability change under the action of temperature and pressure, the higher the temperature, the more significant the permeability change under different confining pressure. The lower the confining pressure, the more significant permeability change under different temperatures. The maximum permeability of sandstone-type uranium ore was obtained under temperature of 80 & DEG;C and confining pressure of 6.0 MPa.