The stratiform manganese deposits, hosted within the Sausar Group of rocks, in Madhya Pradesh state of India, has undergone polyphase deformation and metamorphism. The region is an enterprising geosite to understand the lithological and tectonic control on manganese mineralization. We have carried out a conjugate remote sensing based analysis using Visible, Near Infrared and Short Wave infrared bands (VIS-NIR-SWIR) of optical imagery from multiple sensors supplemented with analysis of L-band microwave data over the Balaghat district of Madhya Pradesh to delineate prospective areas for manganese exploration, supported by the lab and field-based evidence.The enhanced image products (i.e., band ratios, principal components) and spectral anomaly map derived from Advanced Space-borne Thermal Emission and Reflection Radiometer (ASTER) and Sentinel-2B multispectral bands are used to delineate the lithological contrast of the host rock and indicate key locales of mineralization. The geological structures interpreted using the merged product of Advanced Land Observation Satellite Phased Array L-band SAR (ALOS PALSAR -1), Landsat 8 PC bands (2 & 3) and the processed Horizontal Gradient Magnitude (HGM) from advanced satellite gravity model (EIGEN-6C4), illustrates the structural control on the mineralization. The petrological details derived from the host rock samples shows microstructures like micro-folding, foliations, quartz grain elongation etc., thus representing the microscale deformations within the rock units occurring in the area.The lab-based spectral signatures of manganese-bearing host rock was resampled to image spectra and spectral anomaly map using Constrained Energy Minimization (CEM), which shows good correlation with the existing mine locations.The information from remote sensing and lab analysis has been integrated thematically using the knowledge-based Weighted Sum Method (WSM) with existing mine locations as the training dataset. The derived mineral prospect map indicates several new areas of manganese prospectivity which can serve as a guide for detailed exploration in the region in future.