Djerid Chott, in southwestern Tunisia, is one of the biggest salt lakes in the world. This work follows the specific precipitation of evaporites through progressive evaporation of Chott Djerid brines using geochemical, isotopic and mineralogical approaches, to explain the intricacy of the working of saline frameworks controlled basically by climatic driving and the underlying geochemical structure acquired from the geographical system. Toward the finish of every evaporation step, solid and liquid samples went through analyses. Djerid brine is remarkably saline (427.7 g/l) and it is supersaturated contrasted with halite. The outcomes indicated that the Chott Djerid brines shaped fundamentally Cl--Na+-SO4- type geochemistry. Added to halite and gypsum as significant minerals, other minor minerals including carnallite, hexahydrite and sylvite were recognized in various phases of progressive evaporation of Djerid brine. Regardless of their low costs, significant minerals are of geo-economic interest because of their high amounts of production. Then, minor valuable minerals secure their geo-economic interest from their excessive costs. In this work, we find the window of precipitation of these valuable minerals' at the evaporation paces of 80% and 100%.